Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-Accelerated mouse prone 8

Banu Bayram; Sibylle Nikolai; Patricia Huebbe; Beraat Ozcelik; Stefanie Grimm; Tilman Grune; Jan Frank; Gerald Rimbach

doi:10.1007/s11357-012-9448-0

Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-Accelerated mouse prone 8

Banu Bayram, Sibylle Nikolai, Patricia Huebbe, Beraat Ozcelik, Stefanie Grimm, Tilman Grune, Jan Frank, Gerald Rimbach^*

^*Corresponding author for this work

Department of Food Engineering

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

In this study we compared biomarkers of oxidative stress, stress response, antioxidant defence and inflammation between mice (n010 per group, female, 7 months old) with an accelerated (SAMP8) and a normal ageing phenotype (SAMR1). As compared to SAMR1 mice, SAMP8 mice exhibited higher levels of lipid peroxides and protein carbonyls as well as a lower activity of the proteasomal subunit ?-5. Furthermore, heme oxygenase-1 and paraoxonase-1 (PON-1) status was lower in SAMP8 mice indicating impaired stress response. Biomarkers of inflammation such as C-reactive protein and serum amyloid P were elevated in SAMP8 mice. Interestingly, impaired stress response and increased inflammation in SAMP8 mice were associated with elevated concentrations of ascorbic acid and ?-Tocopherol in the liver. An agedependent increase in hepatic vitamin E and a decline in PON-1 gene expression were also observed in aged compared to young C57BL/6 mice

Original language	English
Pages (from-to)	1205-1217
Number of pages	13
Journal	Age
Volume	35
Issue number	4
DOIs	https://doi.org/10.1007/s11357-012-9448-0
Publication status	Published - Aug 2013

Funding

Acknowledgments BB is supported by TUBITAK (The Scientific and Technological Research Council of Turkey). JF is supported by grant no. FR 2478/4-1 from the German Research Foundation (DFG) and grant no. 0315679A from the German Federal Ministry of Education and Research (BMBF). GR is supported by the BMBF and the DFG Cluster of Excellence “Inflammation at Interfaces”.

Funders	Funder number
Deutsche Forschungsgemeinschaft	0315679A
Bundesministerium für Bildung und Forschung
Türkiye Bilimsel ve Teknolojik Araştirma Kurumu	FR 2478/4-1

Keywords

Accelerated ageing
Ascorbic acid
Proteasomal activity
SAMP8
Stress response
Tocopherol

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10.1007/s11357-012-9448-0

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abstract = "In this study we compared biomarkers of oxidative stress, stress response, antioxidant defence and inflammation between mice (n010 per group, female, 7 months old) with an accelerated (SAMP8) and a normal ageing phenotype (SAMR1). As compared to SAMR1 mice, SAMP8 mice exhibited higher levels of lipid peroxides and protein carbonyls as well as a lower activity of the proteasomal subunit ?-5. Furthermore, heme oxygenase-1 and paraoxonase-1 (PON-1) status was lower in SAMP8 mice indicating impaired stress response. Biomarkers of inflammation such as C-reactive protein and serum amyloid P were elevated in SAMP8 mice. Interestingly, impaired stress response and increased inflammation in SAMP8 mice were associated with elevated concentrations of ascorbic acid and ?-Tocopherol in the liver. An agedependent increase in hepatic vitamin E and a decline in PON-1 gene expression were also observed in aged compared to young C57BL/6 mice",

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AU - Bayram, Banu

AU - Nikolai, Sibylle

AU - Huebbe, Patricia

AU - Ozcelik, Beraat

AU - Grimm, Stefanie

AU - Grune, Tilman

AU - Frank, Jan

AU - Rimbach, Gerald

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AB - In this study we compared biomarkers of oxidative stress, stress response, antioxidant defence and inflammation between mice (n010 per group, female, 7 months old) with an accelerated (SAMP8) and a normal ageing phenotype (SAMR1). As compared to SAMR1 mice, SAMP8 mice exhibited higher levels of lipid peroxides and protein carbonyls as well as a lower activity of the proteasomal subunit ?-5. Furthermore, heme oxygenase-1 and paraoxonase-1 (PON-1) status was lower in SAMP8 mice indicating impaired stress response. Biomarkers of inflammation such as C-reactive protein and serum amyloid P were elevated in SAMP8 mice. Interestingly, impaired stress response and increased inflammation in SAMP8 mice were associated with elevated concentrations of ascorbic acid and ?-Tocopherol in the liver. An agedependent increase in hepatic vitamin E and a decline in PON-1 gene expression were also observed in aged compared to young C57BL/6 mice

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Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-Accelerated mouse prone 8

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