Biological properties of 4-trifluoromethylbenzyloxy-substituted cobalt phthalocyanine-gold nanoparticle conjugates

İrem Göller, H. Yasemin Yenilmez*, Nazlı Farajzadeh Öztürk

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In this article, peripheral and non-peripheral cobalt phthalocyanines (2 and 3) were synthesized and characterized by applying the spectroscopic methods (FT-IR, 1H NMR, 13C NMR, Maldi-Toff mass, and UV–vis). The synthesized compounds were used for the surficial modification of gold nanoparticles (AuNP). The novel conjugates (2-AuNP and 3-AuNP) were characterized using transmission electron microscopy. The antioxidant activities of bioagents (2, 3, 2-AuNP, 3-AuNP, and AuNP) were examined by performing three different methods, and the results were compared. When their antioxidant properties were examined, it was shown that the capacities of phthalocyanines were higher compared with the modified gold nanoparticles. In addition, antibacterial analysis of the compounds was carried out by applying two different methods. As a result of the analysis, it was determined that both cobalt phthalocyanines and nanoconjugates showed antibacterial activities against Escherichia coli. Phthalocyanine compounds showed lower IC50 results than phthalocyanine-modified gold nanoparticles, while unmodified gold nanoparticles showed no α-glucosidase inhibitory activity.

Original languageEnglish
Article numbere7505
JournalApplied Organometallic Chemistry
Volume38
Issue number7
DOIs
Publication statusPublished - Jul 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Applied Organometallic Chemistry published by John Wiley & Sons Ltd.

Keywords

  • antibacterial activity
  • antioxidant capacity
  • gold nanoparticles
  • phthalocyanine
  • α-glucosidase inhibition

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