Biological particle manipulation: An example of Jurkat enrichment

Emre Altinagac, Huseyin Kizil, Levent Trabzon

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Dielectrophoresis-based separation of microparticles and living cells are studied with computational and experimental methods. The flow behaviours of particles are modelled and simulated using COMSOL Multiphysics 4.3a software (COMSOL Ltd). Lab-on-a-chip devices having a titanium (Ti) interdigitated electrode layer on a glass substrate and a PDMS microchannel are fabricated to investigate the most effective design for separating particles based on their sizes. Polystyrene particles in different diameters (3.2 and 9.8 ìm) are used in the experiments. Green polystyrene particles from red ones are fully separated in a current design. Enrichment of Jurkat cells having 10.1 average diameter in phosphate buffer solution (PBS) medium is achieved.

Original languageEnglish
Pages (from-to)550-553
Number of pages4
JournalMicro and Nano Letters
Volume10
Issue number10
DOIs
Publication statusPublished - 1 Oct 2015

Bibliographical note

Publisher Copyright:
© The Institution of Engineering and Technology 2015.

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