TY - JOUR
T1 - Biogenic integrated ZnO/Ag nanocomposite
T2 - Surface analysis and in vivo practices for the management of type 1 diabetes complications
AU - Rahim Pouran, Shima
AU - Bayrami, Abolfazl
AU - Mohammadi Arvanag, Farid
AU - Habibi-Yangjeh, Aziz
AU - Darvishi Cheshmeh Soltani, Reza
AU - Singh, Ramesh
AU - Abdul Raman, Abdul Aziz
AU - Chae, Keun Hwa
AU - Khataee, Alireza
AU - Kang, Hee Kyoung
N1 - Publisher Copyright:
© 2020
PY - 2020/5
Y1 - 2020/5
N2 - In this research, a milk thistle seed extract (MTSE)-rich medium was used as a capping and reducing agent for the one-pot biosynthesis of ZnO/Ag (5 wt%) nanostructure. The sample was systematically characterized through various techniques and its strong biomolecule‒metal interface structure was supported by the results. The efficacy of the derived nanostructure (MTSE/ZnO/Ag) was evaluated in vivo on the basis of its therapeutic effects on the main complications of Type 1 diabetes (hyperglycemia, hyperlipidemia, and insulin deficiency). For this purpose, the changes in the plasma values of fasting blood glucose, total cholesterol, total triglyceride, high-density lipoprotein cholesterol, and insulin in alloxan-diabetic Wistar male rats were compared with those in healthy and untreated diabetic controls after a treatment period of 16 days. The antidiabetic results of MTSE/ZnO/Ag were compared with those obtained from pristine ZnO, MTSE, and insulin therapies. The health conditions of the rats with Type 1 diabetes were significantly enhanced after treatment with MTSE/ZnO/Ag (p < 0.05), which is owing to the enhanced interface structure and participatory functions of the united compartments of MTSE/ZnO/Ag.
AB - In this research, a milk thistle seed extract (MTSE)-rich medium was used as a capping and reducing agent for the one-pot biosynthesis of ZnO/Ag (5 wt%) nanostructure. The sample was systematically characterized through various techniques and its strong biomolecule‒metal interface structure was supported by the results. The efficacy of the derived nanostructure (MTSE/ZnO/Ag) was evaluated in vivo on the basis of its therapeutic effects on the main complications of Type 1 diabetes (hyperglycemia, hyperlipidemia, and insulin deficiency). For this purpose, the changes in the plasma values of fasting blood glucose, total cholesterol, total triglyceride, high-density lipoprotein cholesterol, and insulin in alloxan-diabetic Wistar male rats were compared with those in healthy and untreated diabetic controls after a treatment period of 16 days. The antidiabetic results of MTSE/ZnO/Ag were compared with those obtained from pristine ZnO, MTSE, and insulin therapies. The health conditions of the rats with Type 1 diabetes were significantly enhanced after treatment with MTSE/ZnO/Ag (p < 0.05), which is owing to the enhanced interface structure and participatory functions of the united compartments of MTSE/ZnO/Ag.
KW - Bio-metal interface
KW - Hyperglycemia
KW - Hyperlipidemia
KW - Silymarin
KW - Type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85079643928&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2020.110878
DO - 10.1016/j.colsurfb.2020.110878
M3 - Article
C2 - 32087528
AN - SCOPUS:85079643928
SN - 0927-7765
VL - 189
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
M1 - 110878
ER -
