Biocompatibility Evaluation of Dentine, Enamel and Bone Derived Hydroxyapatite

P. Valerio*, F. N. Oktar, L. S. Ozyegin, G. Goller, A. M. Goes, M. F. Leite

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

10 Citations (Scopus)


The biocompatibily of dentine, enamel and bone derived hydroxyapatite was studied using primary culture of osteoblasts. The cell viability, collagen and alkaline phosphatase production and cell morphology were analyzed in the presence of biomaterials powder and compared to control and to osteoblasts in the presence of synthetic hydroxyapatite. Osteoblasts in the presence of bone derived hydroxyapatite showed increased proliferation and collagen production. Dentine and enamel derived hydroxyapatite did not alter cell behavior when compared to control or to synthetic hydroxyapatite.

Original languageEnglish
Pages (from-to)837-840
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2004
EventThe Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal
Duration: 6 Nov 20039 Nov 2003


  • Alkaline phosphatase
  • Biocompatibility
  • Collagen
  • Natural hydroxyapatite
  • Osteoblast


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