Bioactive constituents of Salvia chrysophylla Stapf

Burcu Çulhaoglu, Gönül Yapara, Tuncay Dirmencic, Gülaçt Topçu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


The dichloromethane extract of the aerial parts of Salvia chrysophylla Stapf (Lamiaceae), which is an endemic species to south-western Anatolia, was studied for non-volatile secondary metabolites for the first time in this study. Structures of the isolated compounds were elucidated as sclareol, β-sitosterol, salvigenin, oleanolic acid and ursolic acid. The lipid peroxidation inhibitory activity and the DPPH free radical scavenging activity of the pure isolates were investigated to establish their antioxidant potential. Their anticholinesterase activity was carried out by the Ellman assay against both enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase, and diterpene sclareol exhibited fairly good activity against both the enzymes while the two triterpenoids oleanolic and ursolic acids exhibited selective activity against AChE .

Original languageEnglish
Pages (from-to)438-447
Number of pages10
JournalNatural Product Research
Issue number4-5
Publication statusPublished - 2013


Burcu C¸ ulhaog˘ lu and Gülac¸ t| Topc¸ u thank Istanbul Technical University, Department of Scientific Research Projects, for financial support for this study (Project no. 34100), which is a part of the master’s thesis of Burcu C¸ ulhaog˘ lu.

FundersFunder number
Department of Scientific Research Projects34100
Istanbul Teknik Üniversitesi


    • Anticholinesterase
    • Antioxidant
    • Lamiaceae
    • Salvia chrysophylla
    • Sclareol


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