Avocado–Soybean unsaponifiables: A panoply of potentialities to be exploited

Bahare Salehi, Antonio Rescigno, Tinuccia Dettori, Daniela Calina, Anca Oana Docea, Laxman Singh, Fatma Cebeci, Beraat Özçelik, Mohammed Bhia, Amirreza Dowlati Beirami, Javad Sharifi-Rad*, Farukh Sharopov, William C. Cho, Natália Martins

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

75 Citations (Scopus)


Avocado and soybean unsaponifiables (ASU) constitute vegetable extracts made from fruits and seeds of avocado and soybean oil. Characterized by its potent anti-inflammatory effects, this ASU mixture is recommended to act as an adjuvant treatment for osteoarthritic pain and slow-acting symptomatic treatment of hip and knee osteoarthritis; autoimmune diseases; diffuse scleroderma and scleroderma-like states (e.g., morphea, sclerodactyly, scleroderma in bands). Besides, it was reported that it can improve the mood and quality of life of postmenopausal women in reducing menopause-related symptoms. This article aims to summarize the studies on biological effects of the avocado–soybean unsaponifiable, its chemical composition, pharmacotherapy as well as applications in autoimmune, osteoarticular and menopausal disorders. Finally, we will also discuss on its safety, toxicological and regulatory practices.

Original languageEnglish
Article number130
Issue number1
Publication statusPublished - Jan 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


N. Martins would like to thank the Portuguese Foundation for Science and Technology (FCT-Portugal) for the Strategic project ref. UID/BIM/04293/2013 and “NORTE2020-Northern Regional Operational Program” (NORTE-01-0145-FEDER-000012).

FundersFunder number
Fundação para a Ciência e a TecnologiaUID/BIM/04293/2013, NORTE-01-0145-FEDER-000012


    • Avocado–soybean unsaponifiables
    • Carothenes
    • Menopause
    • Osteoarthritis
    • Phytosterols
    • Scleroderma
    • Tocopherol


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