Aqueous colloidal nanoplatelets for imaging and improved ALA-based photodynamic therapy of prostate cancer cells

Kubra Onbasli; Gozde Demirci; Furkan Isik; Emek Goksu Durmusoglu; Hilmi Volkan Demir; Havva Yagci Acar

doi:10.1039/d3cc02929h

Aqueous colloidal nanoplatelets for imaging and improved ALA-based photodynamic therapy of prostate cancer cells

Kubra Onbasli
, Gozde Demirci
, Furkan Isik
, Emek Goksu Durmusoglu
, Hilmi Volkan Demir^*
, Havva Yagci Acar^*

^*Corresponding author for this work

Koc University
Bilkent University
Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Fluorescent, CdSe/CdS core/crown heterostructured nanoplatelets (NPLs) were transferred to the water via a simple, single-step ligand exchange using 2-mercaptopropionic acid in a simple extraction process. These stable, aqueous NPLs were loaded with a modal drug, 5-aminolevulinic acid (ALA). ALA-loaded NPLs emerged as a new class of theranostic nanoparticles for image-guided enhanced photodynamic therapy of both androgen-dependent and -independent human prostate cancer cells.

Original language	English
Pages (from-to)	10512-10515
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	70
DOIs	https://doi.org/10.1039/d3cc02929h
Publication status	Published - 21 Jul 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 The Royal Society of Chemistry.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1039/d3cc02929h

Cite this

@article{602a7db2842142a68c7f21d1c9092b13,

title = "Aqueous colloidal nanoplatelets for imaging and improved ALA-based photodynamic therapy of prostate cancer cells",

abstract = "Fluorescent, CdSe/CdS core/crown heterostructured nanoplatelets (NPLs) were transferred to the water via a simple, single-step ligand exchange using 2-mercaptopropionic acid in a simple extraction process. These stable, aqueous NPLs were loaded with a modal drug, 5-aminolevulinic acid (ALA). ALA-loaded NPLs emerged as a new class of theranostic nanoparticles for image-guided enhanced photodynamic therapy of both androgen-dependent and -independent human prostate cancer cells.",

author = "Kubra Onbasli and Gozde Demirci and Furkan Isik and Durmusoglu, \{Emek Goksu\} and Demir, \{Hilmi Volkan\} and Acar, \{Havva Yagci\}",

note = "Publisher Copyright: {\textcopyright} 2023 The Royal Society of Chemistry.",

year = "2023",

month = jul,

day = "21",

doi = "10.1039/d3cc02929h",

language = "English",

volume = "59",

pages = "10512--10515",

journal = "Chemical Communications",

issn = "1359-7345",

number = "70",

}

TY - JOUR

T1 - Aqueous colloidal nanoplatelets for imaging and improved ALA-based photodynamic therapy of prostate cancer cells

AU - Onbasli, Kubra

AU - Demirci, Gozde

AU - Isik, Furkan

AU - Durmusoglu, Emek Goksu

AU - Demir, Hilmi Volkan

AU - Acar, Havva Yagci

PY - 2023/7/21

Y1 - 2023/7/21

N2 - Fluorescent, CdSe/CdS core/crown heterostructured nanoplatelets (NPLs) were transferred to the water via a simple, single-step ligand exchange using 2-mercaptopropionic acid in a simple extraction process. These stable, aqueous NPLs were loaded with a modal drug, 5-aminolevulinic acid (ALA). ALA-loaded NPLs emerged as a new class of theranostic nanoparticles for image-guided enhanced photodynamic therapy of both androgen-dependent and -independent human prostate cancer cells.

AB - Fluorescent, CdSe/CdS core/crown heterostructured nanoplatelets (NPLs) were transferred to the water via a simple, single-step ligand exchange using 2-mercaptopropionic acid in a simple extraction process. These stable, aqueous NPLs were loaded with a modal drug, 5-aminolevulinic acid (ALA). ALA-loaded NPLs emerged as a new class of theranostic nanoparticles for image-guided enhanced photodynamic therapy of both androgen-dependent and -independent human prostate cancer cells.

UR - https://www.scopus.com/pages/publications/85168579166

U2 - 10.1039/d3cc02929h

DO - 10.1039/d3cc02929h

M3 - Article

C2 - 37555511

AN - SCOPUS:85168579166

SN - 1359-7345

VL - 59

SP - 10512

EP - 10515

JO - Chemical Communications

JF - Chemical Communications

IS - 70

ER -

Aqueous colloidal nanoplatelets for imaging and improved ALA-based photodynamic therapy of prostate cancer cells

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this