Aqueous colloidal nanoplatelets for imaging and improved ALA-based photodynamic therapy of prostate cancer cells

Kubra Onbasli; Gozde Demirci; Furkan Isik; Emek Goksu Durmusoglu; Hilmi Volkan Demir; Havva Yagci Acar

doi:10.1039/d3cc02929h

Aqueous colloidal nanoplatelets for imaging and improved ALA-based photodynamic therapy of prostate cancer cells

Kubra Onbasli, Gozde Demirci, Furkan Isik, Emek Goksu Durmusoglu, Hilmi Volkan Demir^*, Havva Yagci Acar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Fluorescent, CdSe/CdS core/crown heterostructured nanoplatelets (NPLs) were transferred to the water via a simple, single-step ligand exchange using 2-mercaptopropionic acid in a simple extraction process. These stable, aqueous NPLs were loaded with a modal drug, 5-aminolevulinic acid (ALA). ALA-loaded NPLs emerged as a new class of theranostic nanoparticles for image-guided enhanced photodynamic therapy of both androgen-dependent and -independent human prostate cancer cells.

Original language	English
Pages (from-to)	10512-10515
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	70
DOIs	https://doi.org/10.1039/d3cc02929h
Publication status	Published - 21 Jul 2023
Externally published	Yes

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Publisher Copyright:
© 2023 The Royal Society of Chemistry.

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10.1039/d3cc02929h

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title = "Aqueous colloidal nanoplatelets for imaging and improved ALA-based photodynamic therapy of prostate cancer cells",

abstract = "Fluorescent, CdSe/CdS core/crown heterostructured nanoplatelets (NPLs) were transferred to the water via a simple, single-step ligand exchange using 2-mercaptopropionic acid in a simple extraction process. These stable, aqueous NPLs were loaded with a modal drug, 5-aminolevulinic acid (ALA). ALA-loaded NPLs emerged as a new class of theranostic nanoparticles for image-guided enhanced photodynamic therapy of both androgen-dependent and -independent human prostate cancer cells.",

author = "Kubra Onbasli and Gozde Demirci and Furkan Isik and Durmusoglu, {Emek Goksu} and Demir, {Hilmi Volkan} and Acar, {Havva Yagci}",

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doi = "10.1039/d3cc02929h",

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AU - Onbasli, Kubra

AU - Demirci, Gozde

AU - Isik, Furkan

AU - Durmusoglu, Emek Goksu

AU - Demir, Hilmi Volkan

AU - Acar, Havva Yagci

PY - 2023/7/21

Y1 - 2023/7/21

N2 - Fluorescent, CdSe/CdS core/crown heterostructured nanoplatelets (NPLs) were transferred to the water via a simple, single-step ligand exchange using 2-mercaptopropionic acid in a simple extraction process. These stable, aqueous NPLs were loaded with a modal drug, 5-aminolevulinic acid (ALA). ALA-loaded NPLs emerged as a new class of theranostic nanoparticles for image-guided enhanced photodynamic therapy of both androgen-dependent and -independent human prostate cancer cells.

AB - Fluorescent, CdSe/CdS core/crown heterostructured nanoplatelets (NPLs) were transferred to the water via a simple, single-step ligand exchange using 2-mercaptopropionic acid in a simple extraction process. These stable, aqueous NPLs were loaded with a modal drug, 5-aminolevulinic acid (ALA). ALA-loaded NPLs emerged as a new class of theranostic nanoparticles for image-guided enhanced photodynamic therapy of both androgen-dependent and -independent human prostate cancer cells.

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U2 - 10.1039/d3cc02929h

DO - 10.1039/d3cc02929h

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SN - 1359-7345

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SP - 10512

EP - 10515

JO - Chemical Communications

JF - Chemical Communications

IS - 70

ER -

Aqueous colloidal nanoplatelets for imaging and improved ALA-based photodynamic therapy of prostate cancer cells

Abstract

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