TY - JOUR
T1 - Antimicrobial cerium ion-chitosan crosslinked alginate biopolymer films
T2 - A novel and potential wound dressing
AU - Kaygusuz, Hakan
AU - Torlak, Emrah
AU - Akın-Evingür, Gülşen
AU - Özen, İlhan
AU - von Klitzing, Regine
AU - Erim, F. Bedia
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/12
Y1 - 2017/12
N2 - Wound dressings require good antiseptic properties, mechanical strength and, more trustably, natural material ingredients. Antimicrobial properties of cerium ions and chitosan are known and alginate based wound dressings are commercially available. In this study, the advantages of these materials were combined and alginate films were crosslinked with cerium(III) solution and chitosan added cerium(III) solution. Films were characterized by Fourier transform infrared spectroscopy (FTIR), light transmittance, scanning electron microscopy (SEM), swelling experiments, water vapor transmittance tests, and mechanical stretching tests. The antibacterial and physical properties of the films were compared with those of conventional calcium alginate films. Both cerium ion crosslinked and cerium ion-chitosan crosslinked alginate films gained antibacterial activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. Cerium alginate-chitosan films showed high resistance to being deformed elastically. Results show that cerium alginate-chitosan films can be flexible, ultraviolet-protecting, and antibacterial wound dressings.
AB - Wound dressings require good antiseptic properties, mechanical strength and, more trustably, natural material ingredients. Antimicrobial properties of cerium ions and chitosan are known and alginate based wound dressings are commercially available. In this study, the advantages of these materials were combined and alginate films were crosslinked with cerium(III) solution and chitosan added cerium(III) solution. Films were characterized by Fourier transform infrared spectroscopy (FTIR), light transmittance, scanning electron microscopy (SEM), swelling experiments, water vapor transmittance tests, and mechanical stretching tests. The antibacterial and physical properties of the films were compared with those of conventional calcium alginate films. Both cerium ion crosslinked and cerium ion-chitosan crosslinked alginate films gained antibacterial activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. Cerium alginate-chitosan films showed high resistance to being deformed elastically. Results show that cerium alginate-chitosan films can be flexible, ultraviolet-protecting, and antibacterial wound dressings.
KW - Alginate
KW - Chitosan
KW - Wound dressing
UR - http://www.scopus.com/inward/record.url?scp=85026366834&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2017.07.144
DO - 10.1016/j.ijbiomac.2017.07.144
M3 - Article
C2 - 28751050
AN - SCOPUS:85026366834
SN - 0141-8130
VL - 105
SP - 1161
EP - 1165
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -