Anti-obesity and anti-diabetic bioactive peptides: A comprehensive review of their sources, properties, and techno-functional challenges

Tolulope Joshua Ashaolu, Opeyemi Joshua Olatunji, Asli Can Karaca, Chi Ching Lee, Seid Mahdi Jafari*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The scourge of obesity arising from obesogens and poor dieting still ravages our planet as half of the global population may be overweight and obese by 2035. This metabolic disorder is intertwined with type 2 diabetes (T2D), both of which warrant alternative therapeutic options other than clinically approved drugs like orlistat with their tendency of abuse and side effects. In this review, we comprehensively describe the global obesity problem and its connection to T2D. Obesity, overconsumption of fats, the mechanism of fat digestion, obesogenic gut microbiota, inhibition of fat digestion, and natural anti-obesity compounds are discussed. Similar discussions are made for diabetes with regard to glucose regulation, the diabetic gut microbiota, and insulinotropic compounds. The sources and production of anti-obesity bioactive peptides (AOBPs) and anti-diabetic bioactive peptides (ADBPs) are also described while explaining their structure–function relationships, gastrointestinal behaviors, and action mechanisms. Finally, the techno-functional applications of AOBPs and ADBPs are highlighted.

Original languageEnglish
Article number114427
JournalFood Research International
Volume187
DOIs
Publication statusPublished - Jul 2024

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Ltd

Keywords

  • Bioactive peptides
  • Diabetes
  • Mechanism of action
  • Obesity
  • Structure–function
  • Techno-function

Fingerprint

Dive into the research topics of 'Anti-obesity and anti-diabetic bioactive peptides: A comprehensive review of their sources, properties, and techno-functional challenges'. Together they form a unique fingerprint.

Cite this