Anthocyanin absorption and metabolism by human intestinal Caco-2 cells—A review

Senem Kamiloglu, Esra Capanoglu*, Charlotte Grootaert, John van Camp

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

178 Citations (Scopus)

Abstract

Anthocyanins from different plant sources have been shown to possess health beneficial effects against a number of chronic diseases. To obtain any influence in a specific tissue or organ, these bioactive compounds must be bioavailable, i.e., effectively absorbed from the gut into the circulation and transferred to the appropriate location within the body while still maintaining their bioactivity. One of the key factors affecting the bioavailability of anthocyanins is their transport through the gut epithelium. The Caco-2 cell line, a human intestinal epithelial cell model derived from a colon carcinoma, has been proven to be a good alternative to animal studies for predicting intestinal absorption of anthocyanins. Studies investigating anthocyanin absorption by Caco-2 cells report very low absorption of these compounds. However, the bioavailability of anthocyanins may be underestimated since the metabolites formed in the course of digestion could be responsible for the health benefits associated with anthocyanins. In this review, we critically discuss recent findings reported on the anthocyanin absorption and metabolism by human intestinal Caco-2 cells.

Original languageEnglish
Pages (from-to)21555-21574
Number of pages20
JournalInternational Journal of Molecular Sciences
Volume16
Issue number9
DOIs
Publication statusPublished - 8 Sept 2015

Bibliographical note

Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

Funding

FundersFunder number
Seventh Framework Programme312090

    Keywords

    • Anthocyanins
    • Caco-2 cells
    • Intestinal absorption
    • Metabolism

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