Angiotensin-I-converting enzyme (ACE)-inhibitory peptides from plants

Ceren Daskaya-Dikmen, Aysun Yucetepe, Funda Karbancioglu-Guler, Hayrettin Daskaya, Beraat Ozcelik*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

243 Citations (Scopus)


Hypertension is an important factor in cardiovascular diseases. Angiotensin-I-converting enzyme (ACE) inhibitors like synthetic drugs are widely used to control hypertension. ACE-inhibitory peptides from food origins could be a good alternative to synthetic drugs. A number of plant-based peptides have been investigated for their potential ACE inhibitor activities by using in vitro and in vivo assays. These plant-based peptides can be obtained by solvent extraction, enzymatic hydrolysis with or without novel food processing methods, and fermentation. ACE-inhibitory activities of peptides can be affected by their structural characteristics such as chain length, composition and sequence. ACE-inhibitory peptides should have gastrointestinal stability and reach the cardiovascular system to show their bioactivity. This paper reviews the current literature on plant-derived ACE-inhibitory peptides including their sources, production and structure, as well as their activity by in vitro and in vivo studies and their bioavailability.

Original languageEnglish
Article number316
Issue number4
Publication statusPublished - 1 Apr 2017

Bibliographical note

Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.


  • Angiotensin-I-converting enzyme inhibitory activity
  • Bioactive peptides
  • Bioavailability
  • Diabetes
  • Enzymatic hydrolysis
  • Obesity
  • Plant proteins


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