Aminolated and Thiolated PEG-Covered Gold Nanoparticles with High Stability and Antiaggregation for Lateral Flow Detection of Bisphenol A

Li Kai Lin; Aytekin Uzunoglu; Lia A. Stanciu

doi:10.1002/smll.201702828

Aminolated and Thiolated PEG-Covered Gold Nanoparticles with High Stability and Antiaggregation for Lateral Flow Detection of Bisphenol A

Li Kai Lin^*, Aytekin Uzunoglu, Lia A. Stanciu

^*Corresponding author for this work

Purdue University, School of Electrical and Computer Engineering

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

The few lateral flow assays (LFAs) established for detecting the endocrine disrupting chemical bisphenol A (BPA) have employed citrate-stabilized gold nanoparticles (GNPs), which have inevitable limitations and instability issues. To address these limitations, a more stable and more sensitive biosensor is developed by designing strategies for modifying the surfaces of GNPs with polyethylene glycol and then testing their effectiveness and sensitivity toward BPA in an LFA. Without the application of any enhancement strategy, this modified BPA LFA can achieve a naked-eye limit of detection (LOD) of 0.8 ng mL⁻¹, which is 12.5 times better than the LOD of regular BPA LFAs, and a quantitative LOD of 0.472 ng mL⁻¹. This modified LFA has the potential to be applied to the detection of various antigens.

Original language	English
Article number	1702828
Journal	Small
Volume	14
Issue number	10
DOIs	https://doi.org/10.1002/smll.201702828
Publication status	Published - 8 Mar 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

BPA
PEGylated nanoparticles
immunochromatographic assays
lateral flow

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10.1002/smll.201702828

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abstract = "The few lateral flow assays (LFAs) established for detecting the endocrine disrupting chemical bisphenol A (BPA) have employed citrate-stabilized gold nanoparticles (GNPs), which have inevitable limitations and instability issues. To address these limitations, a more stable and more sensitive biosensor is developed by designing strategies for modifying the surfaces of GNPs with polyethylene glycol and then testing their effectiveness and sensitivity toward BPA in an LFA. Without the application of any enhancement strategy, this modified BPA LFA can achieve a naked-eye limit of detection (LOD) of 0.8 ng mL−1, which is 12.5 times better than the LOD of regular BPA LFAs, and a quantitative LOD of 0.472 ng mL−1. This modified LFA has the potential to be applied to the detection of various antigens.",

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AU - Uzunoglu, Aytekin

AU - Stanciu, Lia A.

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AB - The few lateral flow assays (LFAs) established for detecting the endocrine disrupting chemical bisphenol A (BPA) have employed citrate-stabilized gold nanoparticles (GNPs), which have inevitable limitations and instability issues. To address these limitations, a more stable and more sensitive biosensor is developed by designing strategies for modifying the surfaces of GNPs with polyethylene glycol and then testing their effectiveness and sensitivity toward BPA in an LFA. Without the application of any enhancement strategy, this modified BPA LFA can achieve a naked-eye limit of detection (LOD) of 0.8 ng mL−1, which is 12.5 times better than the LOD of regular BPA LFAs, and a quantitative LOD of 0.472 ng mL−1. This modified LFA has the potential to be applied to the detection of various antigens.

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Aminolated and Thiolated PEG-Covered Gold Nanoparticles with High Stability and Antiaggregation for Lateral Flow Detection of Bisphenol A

Abstract

Bibliographical note

Keywords

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