Acute impact of tetracycline and erythromycin on the storage mechanism of polyhydroxyalkanoates

Tugce Katipoglu-Yazan*, Ilke Pala-Ozkok, Emine Ubay-Cokgor, Derin Orhon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


The study investigated acute impact of tetracycline and erythromycin on substrate storage under aerobic conditions. A fill and draw reactor fed with peptone mixture was maintained at steady-state at a sludge age of 10 days; the acclimated biomass was used in a series of batch runs. The first run served as control reactor with organic substrate alone and the others were started with antibiotic doses of 50. mg/L and 200. mg/L for assessing intracellular storage. Parallel batch reactors were also conducted for recording oxygen uptake rate profiles. Both antibiotics enhanced substrate storage, leading to higher levels of polyhydroxyalkanoates incorporated into biomass, but they impaired its internal utilization for microbial growth. The observed decrease in oxygen consumption under the acute effect of antibiotics could partially be related to substrate storage - except for 50. mg/L of erythromycin dosing - suggesting an additional substrate binding mechanism by antibiotics, leading to residual biodegradable substrate.

Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalBiochemical Engineering Journal
Publication statusPublished - 5 Oct 2014

Bibliographical note

Publisher Copyright:
© 2014 Elsevier B.V.


This study was conducted as a part of the project “Evaluation of the Biodegradation Characteristics and Toxicity/Inhibition Effects of Selected Antibiotics on Nitrification Systems” and supported by joint doctoral degree program of Turkish Academy of Sciences and Scientific Research Fund of Istanbul Technical University.

FundersFunder number
Istanbul Teknik Üniversitesi


    • Antibiotic
    • Dissolved oxygen
    • Kinetic parameters
    • Peptone
    • Polyhydroxyalkanoates
    • Substrate storage


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