A simple spectrophotometric procedure for determination of valaciclovir in dosage forms and biological fluids

Derya Tarinc*, Aysegul Golcu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A simple and selective spectrophotometric procedure for the determination of Valaciclovir (VALA) is proposed and applied to determine the substance in tablets and biological fluids. This procedure is proposed for the determination of VALA in Britton-Robinson (BR) buffer at pH 6.0, which allows quantification over the 4 × 10-6 to 6 × 10-5 M range for spectrophotometric measurements. The repeatability and reproducibilty of the procedure for serum and breast milk samples are estimated. Precision and accuracy are also checked. The standard additions method is used for biological fluids. The proposed produce was verified for the determination of VALA in real human serum, breast milk samples; the selectivity over the metabolites was found to be quite satisfactory.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalJournal of Analytical Chemistry
Volume68
Issue number1
DOIs
Publication statusPublished - Jan 2013
Externally publishedYes

Funding

This research was supported by a grant TUBITAK (grant no. 109T020) for Assoc. Prof. Dr. Aysegul Golcu. The authors gratefully acknowledge the funding of this work by the Research Fund (project no. 2009/3 10) of Kahramanmara¸s Sütçü I·mam University, Kahraman mara¸s, Turkey.

FundersFunder number
Kahramanmara¸s Sütçü I·mam University
TUBITAK109T020

    Keywords

    • biological fluids
    • spectrophotometry

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