Abstract
A simple and selective spectrophotometric procedure for the determination of Valaciclovir (VALA) is proposed and applied to determine the substance in tablets and biological fluids. This procedure is proposed for the determination of VALA in Britton-Robinson (BR) buffer at pH 6.0, which allows quantification over the 4 × 10-6 to 6 × 10-5 M range for spectrophotometric measurements. The repeatability and reproducibilty of the procedure for serum and breast milk samples are estimated. Precision and accuracy are also checked. The standard additions method is used for biological fluids. The proposed produce was verified for the determination of VALA in real human serum, breast milk samples; the selectivity over the metabolites was found to be quite satisfactory.
| Original language | English |
|---|---|
| Pages (from-to) | 27-32 |
| Number of pages | 6 |
| Journal | Journal of Analytical Chemistry |
| Volume | 68 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2013 |
| Externally published | Yes |
Funding
This research was supported by a grant TUBITAK (grant no. 109T020) for Assoc. Prof. Dr. Aysegul Golcu. The authors gratefully acknowledge the funding of this work by the Research Fund (project no. 2009/3 10) of Kahramanmara¸s Sütçü I·mam University, Kahraman mara¸s, Turkey.
| Funders | Funder number |
|---|---|
| Kahramanmara¸s Sütçü I·mam University | |
| TUBITAK | 109T020 |
Keywords
- biological fluids
- spectrophotometry