A short new route to the pyrido[2,3,4-kl]acridine subunit common to pyridoacridine alkaloids of marine origin

Naji M. Ali; Shital K. Chattopadhyay; Alexander McKillop; Roxanne M. Perret-Gentil; Turan Ozturk; Ricardo A. Rebelo

doi:10.1039/C39920001453

A short new route to the pyrido[2,3,4-kl]acridine subunit common to pyridoacridine alkaloids of marine origin

Naji M. Ali
, Shital K. Chattopadhyay
, Alexander McKillop^*
, Roxanne M. Perret-Gentil
, Turan Ozturk
, Ricardo A. Rebelo

^*Corresponding author for this work

University of East Anglia

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

A short new route to the pyrido[2,3,4-kl]acridine ring system has been developed from readily available quinoline precursors involving two key steps: (i) a palladium(0)-catalysed Suzuki cross-coupling reaction of 4-chloroquinolines with arylboronic acids, and (ii) an intramolecular nitrene insertion reaction of the nitrenes derived from 4-phenyl-5-azidoquinolines.

Original language	English
Pages (from-to)	1453-1454
Number of pages	2
Journal	Journal of the Chemical Society D: Chemical Communications
Issue number	19
DOIs	https://doi.org/10.1039/C39920001453
Publication status	Published - 1992
Externally published	Yes

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title = "A short new route to the pyrido[2,3,4-kl]acridine subunit common to pyridoacridine alkaloids of marine origin",

abstract = "A short new route to the pyrido[2,3,4-kl]acridine ring system has been developed from readily available quinoline precursors involving two key steps: (i) a palladium(0)-catalysed Suzuki cross-coupling reaction of 4-chloroquinolines with arylboronic acids, and (ii) an intramolecular nitrene insertion reaction of the nitrenes derived from 4-phenyl-5-azidoquinolines.",

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year = "1992",

doi = "10.1039/C39920001453",

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journal = "Journal of the Chemical Society D: Chemical Communications",

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AU - Ali, Naji M.

AU - Chattopadhyay, Shital K.

AU - McKillop, Alexander

AU - Perret-Gentil, Roxanne M.

AU - Ozturk, Turan

AU - Rebelo, Ricardo A.

PY - 1992

Y1 - 1992

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AB - A short new route to the pyrido[2,3,4-kl]acridine ring system has been developed from readily available quinoline precursors involving two key steps: (i) a palladium(0)-catalysed Suzuki cross-coupling reaction of 4-chloroquinolines with arylboronic acids, and (ii) an intramolecular nitrene insertion reaction of the nitrenes derived from 4-phenyl-5-azidoquinolines.

UR - https://www.scopus.com/pages/publications/0026775181

U2 - 10.1039/C39920001453

DO - 10.1039/C39920001453

M3 - Article

AN - SCOPUS:0026775181

SN - 0022-4936

SP - 1453

EP - 1454

JO - Journal of the Chemical Society D: Chemical Communications

JF - Journal of the Chemical Society D: Chemical Communications

IS - 19

ER -

A short new route to the pyrido[2,3,4-kl]acridine subunit common to pyridoacridine alkaloids of marine origin

Abstract

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