A novel porphyrin derivative and its metal complexes: Electrochemical, photoluminescence, thermal, DNA-binding and superoxide dismutase activity studies

Savaş Purtaş, Muhammet Köse, Ferhan Tümer, Mehmet Tümer*, Ayşegül Gölcü, Gökhan Ceyhan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

In this study, a new porphyrin-Schiff base ligand (L) and its metal complexes (Cu(II), Fe(III), Mn(III), Pt(II) and Zn(II)) were synthesized. The starting material 4-ethyl-2,6-bis(hydroxymethyl)phenol (A) was synthesized from 4-ethylphenol and formaldehyde in the alkaline media. The compound (A) was then oxidized to the 4-ethyl-2,6-diformylphenol (B). The starting compounds (A) and (B) were obtained as single crystals. Structures of the compounds (A) and (B) were determined by the X-ray crytallography technique. The porphyrin ligand (L) and its metal complexes were characterized by the analytical and spectroscopic methods. Electronic, electrochemical and thermal properties of the synthesised compounds were investigated. Superoxide dismutase activities (SOD) of the porphyrin Schiff base complexes were investigated and results were discussed. Additionally, the DNA (fish sperm FSdsDNA) binding studies of the complexes were performed using UV-vis spectroscopy. Competitive studies with ethidium bromide (EB) show that the compounds interact efficiently with DNA through an intercalating way.

Original languageEnglish
Pages (from-to)293-307
Number of pages15
JournalJournal of Molecular Structure
Volume1105
DOIs
Publication statusPublished - 5 Feb 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Funding

We are grateful to The Scientific & Technological Research Council of Turkey (TUBITAK) (Project number: 113Z907) for the support of this research. The authors are also grateful to the Department of Chemistry, Loughborough University for X-ray data collection.

FundersFunder number
Scientific & Technological Research Council of Turkey
TUBITAK113Z907

    Keywords

    • DNA-binding
    • Porphyrin-Schiff base
    • Superoxide dismutase activity
    • X-ray

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