A novel micro drill design based on Ros-DrillⒸ

Handan Nak; Ali Fuat Ergenc

doi:10.1007/s10544-019-0432-7

A novel micro drill design based on Ros-Drill^Ⓒ

Handan Nak^*, Ali Fuat Ergenc

^*Corresponding author for this work

Department of Control and Automation Engineering

Istanbul Technical University

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

This paper presents the development of a novel micro drill device for single living organisms. Currently, microinjection for mice and some other species is performed with the help of piezo-driven actuators with a very small amount of mercury column in the proximal end of the pipette in order to increase the success rate. However, the toxicity of mercury exhibits a risk factor both for the operator and the injected cells. Therefore, mercury-free devices have become a necessity. Here, a novel micro drill is developed based on the same principle of Ros-Drill^Ⓒ piercing approach; piercing via rotational movements. The new drill is driven by a brushless motor, and it incorporates the micropipette holder. Both the amplitude and the frequency of rotational oscillations can be adjusted in very wide ranges. The experiments reveal that the drill is suitable for different tasks such as microinjection and biopsy of different organisms. It presents good performance in terms of success rate, ease of usage, compactness and compatibility with different manipulation systems.

Original language	English
Article number	84
Journal	Biomedical Microdevices
Volume	21
Issue number	4
DOIs	https://doi.org/10.1007/s10544-019-0432-7
Publication status	Published - 1 Dec 2019

Bibliographical note

Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Funding

The authors would like to thank for Dr. Ali Cihan Taskin and Ahmet Kocabay for their permission to use their facilities and conducting the mouse experiments at Koc University Research Center for Translational Medicine. The authors also wish to thank Asst. Prof. Dr. Askin Kocabas for conducting worm experiments in his laboratory at Koc University Departments in Physics. Finally, the authors appreciate Prof. Dr. Seyhan Onbasioglu for her permission to use their high-speed camera at Istanbul Technical University Mechanical Engineering Department.

Funders	Funder number
Istanbul Technical University Mechanical Engineering Department

Keywords

BLDC motor
C. elegans worm injection
ICSI
Micro drill
Rotational oscillations

Access to Document

10.1007/s10544-019-0432-7

Cite this

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title = "A novel micro drill design based on Ros-DrillⒸ ",

abstract = "This paper presents the development of a novel micro drill device for single living organisms. Currently, microinjection for mice and some other species is performed with the help of piezo-driven actuators with a very small amount of mercury column in the proximal end of the pipette in order to increase the success rate. However, the toxicity of mercury exhibits a risk factor both for the operator and the injected cells. Therefore, mercury-free devices have become a necessity. Here, a novel micro drill is developed based on the same principle of Ros-DrillⒸ piercing approach; piercing via rotational movements. The new drill is driven by a brushless motor, and it incorporates the micropipette holder. Both the amplitude and the frequency of rotational oscillations can be adjusted in very wide ranges. The experiments reveal that the drill is suitable for different tasks such as microinjection and biopsy of different organisms. It presents good performance in terms of success rate, ease of usage, compactness and compatibility with different manipulation systems.",

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