Abstract
Our previous study on castor oil (CO) and poly(ethylene glycol) (PEG)-based shape memory polyurethane (PU) films indicated that cell spreading on the polymer surface, cell morphology, and adhesion of fibroblast are closely related to the composition of the polymer that influences surface properties. This integrated experimental and computational study is designed to investigate the effect of important parameters such as surface roughness, crystallinity, hydrophilicity, distribution of hard/soft segments, and topology of the surface on protein adsorption for CO- and PEG-based PUs. Analyses indicate that the crystallinity percentage highly promotes bovine serum albumin (BSA) adsorption. Roughness together with topological features determines BSA adsorption rate and concentration. Hydrophilicity and hard segment content seem to have less critical effect on adsorption. Distribution of hard segments into the soft segments emerges as another important factor for protein adsorption.
| Original language | English |
|---|---|
| Article number | 45669 |
| Journal | Journal of Applied Polymer Science |
| Volume | 135 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 10 Jan 2018 |
Bibliographical note
Publisher Copyright:© 2017 Wiley Periodicals, Inc.
Funding
The authors thank the Istanbul Technical University Scientific Research Project Foundation (ITU BAP) with Project Numbers 37499 and 38147 for their support.
| Funders | Funder number |
|---|---|
| Istanbul Technical University Scientific Research Project Foundation | ITU BAP, 38147, 37499 |
Keywords
- adsorption
- biomedical applications
- polyurethane
- proteins
- surfaces and interfaces