A Mini-Review about Imidazopyridines: Syntheses, Biological Activites, and Reactions

Imidazo[1,2-a]pyridine is a powerful molecule, with thousands of references in the literature. The main reason is that the very positions of nitrogen atoms within the heterocyclic ring give rise to a wide range of activities. It is used as an enzyme inhibitor (for example, c-MET kinase, tyrosine kinase, serine/threonine kinase), antimicrobial agent (for Gram positive and negative bacteria), antitubercular compounds, nematicides and fungicides, antiviral agents against HIV viruses, and some reports mention of antifungal activity, anticancer activity (for example, PC-3 and MDA-MB-231, B16F10, MCF-7, HCT116, and HepG2 are discussed in this paper) and some metal complexes as mRNA inhibitor and sensor devices and their syntheses and related applications are becoming quite important in the chemical community. In this review article, we will discuss the biological activities and chemical synthesis methods of this heterocyclic compound, including its synthesis and the synthesis of other molecules starting from it. We also discussed the effect of substituents on the biological activity of the final compounds, where applicable. It is hoped that the readers will find this treatise useful.