A micropillar-based microfluidic viscometer for Newtonian and non-Newtonian fluids

Adil Mustafa; Aysenur Eser; Ali Cenk Aksu; Alper Kiraz; Melikhan Tanyeri; Ahmet Erten; Ozlem Yalcin

doi:10.1016/j.aca.2020.07.039

A micropillar-based microfluidic viscometer for Newtonian and non-Newtonian fluids

Adil Mustafa
, Aysenur Eser
, Ali Cenk Aksu
, Alper Kiraz^*
, Melikhan Tanyeri^*
, Ahmet Erten^*
, Ozlem Yalcin^*

^*Corresponding author for this work

Department of Electronics and Communication Engineering

Koc University
Department of Physics
Department of Engineering
Duquesne University
Research Center for Translational Medicine

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

In this study, a novel viscosity measurement technique based on measuring the deflection of flexible (poly) dimethylsiloxane (PDMS) micropillars is presented. The experimental results show a nonlinear relationship between fluid viscosity and the deflection of micropillars due to viscoelastic properties of PDMS. A calibration curve, demonstrating this nonlinear relationship, is generated, and used to determine the viscosity of an unknown fluid. Using our method, viscosity measurements for Newtonian fluids (glycerol/water solutions) can be performed within 2–100 cP at shear rates γ = 60.5–398.4 s⁻¹. We also measured viscosity of human whole blood samples (non-Newtonian fluid) yielding 2.7–5.1 cP at shear rates γ = 120–345.1 s⁻¹, which compares well with measurements using conventional rotational viscometers (3.6–5.7 cP). With a sensitivity better than 0.5 cP, this method has the potential to be used as a portable microfluidic viscometer for real-time rheological studies.

Original language	English
Pages (from-to)	107-115
Number of pages	9
Journal	Analytica Chimica Acta
Volume	1135
DOIs	https://doi.org/10.1016/j.aca.2020.07.039
Publication status	Published - 23 Oct 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier B.V.

Funding

This study was supported by Turkish Scientific and Technological Research Council grant SBAG-115S120. This study was supported by Turkish Scientific and Technological Research Council grant SBAG-115S120 .

Funders	Funder number
Turkish Scientific and Technological Research Council	SBAG-115S120
Consejo Nacional para Investigaciones CientÃficas y TecnolÃ³gicas

Keywords

Blood
Deflection
Microfluidics
Micropillars
Rheology
Viscosity

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10.1016/j.aca.2020.07.039

Cite this

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title = "A micropillar-based microfluidic viscometer for Newtonian and non-Newtonian fluids",

abstract = "In this study, a novel viscosity measurement technique based on measuring the deflection of flexible (poly) dimethylsiloxane (PDMS) micropillars is presented. The experimental results show a nonlinear relationship between fluid viscosity and the deflection of micropillars due to viscoelastic properties of PDMS. A calibration curve, demonstrating this nonlinear relationship, is generated, and used to determine the viscosity of an unknown fluid. Using our method, viscosity measurements for Newtonian fluids (glycerol/water solutions) can be performed within 2{\textendash}100 cP at shear rates γ = 60.5{\textendash}398.4 s−1. We also measured viscosity of human whole blood samples (non-Newtonian fluid) yielding 2.7{\textendash}5.1 cP at shear rates γ = 120{\textendash}345.1 s−1, which compares well with measurements using conventional rotational viscometers (3.6{\textendash}5.7 cP). With a sensitivity better than 0.5 cP, this method has the potential to be used as a portable microfluidic viscometer for real-time rheological studies.",

keywords = "Blood, Deflection, Microfluidics, Micropillars, Rheology, Viscosity",

author = "Adil Mustafa and Aysenur Eser and Aksu, \{Ali Cenk\} and Alper Kiraz and Melikhan Tanyeri and Ahmet Erten and Ozlem Yalcin",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = oct,

day = "23",

doi = "10.1016/j.aca.2020.07.039",

language = "English",

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T1 - A micropillar-based microfluidic viscometer for Newtonian and non-Newtonian fluids

AU - Mustafa, Adil

AU - Eser, Aysenur

AU - Aksu, Ali Cenk

AU - Kiraz, Alper

AU - Tanyeri, Melikhan

AU - Erten, Ahmet

AU - Yalcin, Ozlem

PY - 2020/10/23

Y1 - 2020/10/23

N2 - In this study, a novel viscosity measurement technique based on measuring the deflection of flexible (poly) dimethylsiloxane (PDMS) micropillars is presented. The experimental results show a nonlinear relationship between fluid viscosity and the deflection of micropillars due to viscoelastic properties of PDMS. A calibration curve, demonstrating this nonlinear relationship, is generated, and used to determine the viscosity of an unknown fluid. Using our method, viscosity measurements for Newtonian fluids (glycerol/water solutions) can be performed within 2–100 cP at shear rates γ = 60.5–398.4 s−1. We also measured viscosity of human whole blood samples (non-Newtonian fluid) yielding 2.7–5.1 cP at shear rates γ = 120–345.1 s−1, which compares well with measurements using conventional rotational viscometers (3.6–5.7 cP). With a sensitivity better than 0.5 cP, this method has the potential to be used as a portable microfluidic viscometer for real-time rheological studies.

AB - In this study, a novel viscosity measurement technique based on measuring the deflection of flexible (poly) dimethylsiloxane (PDMS) micropillars is presented. The experimental results show a nonlinear relationship between fluid viscosity and the deflection of micropillars due to viscoelastic properties of PDMS. A calibration curve, demonstrating this nonlinear relationship, is generated, and used to determine the viscosity of an unknown fluid. Using our method, viscosity measurements for Newtonian fluids (glycerol/water solutions) can be performed within 2–100 cP at shear rates γ = 60.5–398.4 s−1. We also measured viscosity of human whole blood samples (non-Newtonian fluid) yielding 2.7–5.1 cP at shear rates γ = 120–345.1 s−1, which compares well with measurements using conventional rotational viscometers (3.6–5.7 cP). With a sensitivity better than 0.5 cP, this method has the potential to be used as a portable microfluidic viscometer for real-time rheological studies.

KW - Blood

KW - Deflection

KW - Microfluidics

KW - Micropillars

KW - Rheology

KW - Viscosity

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M3 - Article

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VL - 1135

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JO - Analytica Chimica Acta

JF - Analytica Chimica Acta

ER -

A micropillar-based microfluidic viscometer for Newtonian and non-Newtonian fluids

Abstract

Bibliographical note

Funding

Keywords

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