Abstract
A new and efficient method for the synthesis of 6-chloro-substituted 2-methylene-2,3-dihydro-1,4-oxazepines has been demonstrated. Upon treatment with N-chlorosuccinimide in acetonitrile, N-propargylic β-enaminones underwent chlorination to afford α-chlorinated N-propargylic β-enaminones, which was then subjected to electrophilic cyclization with zinc chloride in refluxing chloroform to yield 6-chloro-2-methylene-2,3-dihydro-1,4-oxazepines. It was shown for the first time that on N-propargylic β-enaminone systems, α-chlorination exclusively preponderates over the formation of chloronium ion. The method was found to be general for a diversity of N-propargylic β-enaminones and tolerated the presence of a wide range of aryl, heteroaryl and alkyl groups with electron-donating and electron-withdrawing substituents. The method was also applicable as the one-pot two-step process without isolating the intermediate α-chlorinated N-propargylic β-enaminones. This operationally easy method may provide a rapid entry to a library of highly functionalized 6-chloro-2-methylene-2,3-dihydro-1,4-oxazepines with potential medicinal applications for human health.
Original language | English |
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Article number | 131650 |
Journal | Tetrahedron |
Volume | 76 |
Issue number | 48 |
DOIs | |
Publication status | Published - 27 Nov 2020 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2020 Elsevier Ltd
Keywords
- 1,4-Oxazepine
- Alkynes
- Cyclization
- N-chlorosuccinimide
- N-Propargylic β-enaminone
- Zinc chloride