TY - JOUR
T1 - A dense residual U-net for multiple sclerosis lesions segmentation from multi-sequence 3D MR images
AU - Sarica, Beytullah
AU - Seker, Dursun Zafer
AU - Bayram, Bulent
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2023/2
Y1 - 2023/2
N2 - Multiple Sclerosis (MS) is an autoimmune disease that causes brain and spinal cord lesions, which magnetic resonance imaging (MRI) can detect and characterize. Recently, deep learning methods have achieved remarkable results in the automated segmentation of MS lesions from MRI data. Hence, this study proposes a novel dense residual U-Net model that combines attention gate (AG), efficient channel attention (ECA), and Atrous Spatial Pyramid Pooling (ASPP) to enhance the performance of the automatic MS lesion segmentation using 3D MRI sequences. First, convolution layers in each block of the U-Net architecture are replaced by residual blocks and connected densely. Then, AGs are exploited to capture salient features passed through the skip connections. The ECA module is appended at the end of each residual block and each downsampling block of U-Net. Later, the bottleneck of U-Net is replaced with the ASSP module to extract multi-scale contextual information. Furthermore, 3D MR images of Fluid Attenuated Inversion Recovery (FLAIR), T1-weighted (T1-w), and T2-weighted (T2-w) are exploited jointly to perform better MS lesion segmentation. The proposed model is validated on the publicly available ISBI2015 and MSSEG2016 challenge datasets. This model produced an ISBI score of 92.75, a mean Dice score of 66.88%, a mean positive predictive value (PPV) of 86.50%, and a mean lesion-wise true positive rate (LTPR) of 60.64% on the ISBI2015 testing set. Also, it achieved a mean Dice score of 67.27%, a mean PPV of 65.19%, and a mean sensitivity of 74.40% on the MSSEG2016 testing set. The results show that the proposed model performs better than the results of some experts and some of the other state-of-the-art methods realized related to this particular subject. Specifically, the best Dice score and the best LTPR are obtained on the ISBI2015 testing set by using the proposed model to segment MS lesions.
AB - Multiple Sclerosis (MS) is an autoimmune disease that causes brain and spinal cord lesions, which magnetic resonance imaging (MRI) can detect and characterize. Recently, deep learning methods have achieved remarkable results in the automated segmentation of MS lesions from MRI data. Hence, this study proposes a novel dense residual U-Net model that combines attention gate (AG), efficient channel attention (ECA), and Atrous Spatial Pyramid Pooling (ASPP) to enhance the performance of the automatic MS lesion segmentation using 3D MRI sequences. First, convolution layers in each block of the U-Net architecture are replaced by residual blocks and connected densely. Then, AGs are exploited to capture salient features passed through the skip connections. The ECA module is appended at the end of each residual block and each downsampling block of U-Net. Later, the bottleneck of U-Net is replaced with the ASSP module to extract multi-scale contextual information. Furthermore, 3D MR images of Fluid Attenuated Inversion Recovery (FLAIR), T1-weighted (T1-w), and T2-weighted (T2-w) are exploited jointly to perform better MS lesion segmentation. The proposed model is validated on the publicly available ISBI2015 and MSSEG2016 challenge datasets. This model produced an ISBI score of 92.75, a mean Dice score of 66.88%, a mean positive predictive value (PPV) of 86.50%, and a mean lesion-wise true positive rate (LTPR) of 60.64% on the ISBI2015 testing set. Also, it achieved a mean Dice score of 67.27%, a mean PPV of 65.19%, and a mean sensitivity of 74.40% on the MSSEG2016 testing set. The results show that the proposed model performs better than the results of some experts and some of the other state-of-the-art methods realized related to this particular subject. Specifically, the best Dice score and the best LTPR are obtained on the ISBI2015 testing set by using the proposed model to segment MS lesions.
KW - Convolutional neural networks
KW - Deep learning
KW - MRI
KW - MS lesion segmentation
KW - Multiple sclerosis (MS)
KW - Residual blocks
KW - U-net
UR - http://www.scopus.com/inward/record.url?scp=85144605442&partnerID=8YFLogxK
U2 - 10.1016/j.ijmedinf.2022.104965
DO - 10.1016/j.ijmedinf.2022.104965
M3 - Article
C2 - 36580821
AN - SCOPUS:85144605442
SN - 1386-5056
VL - 170
JO - International Journal of Medical Informatics
JF - International Journal of Medical Informatics
M1 - 104965
ER -