A 3D co-culture intestinal organoid system for exploring glucose metabolism

Jianping Nie, Wei Liao, Zijie Zhang, Minjiao Zhang, Yuxi Wen, Esra Capanoglu, Md Moklesur Rahman Sarker, Ruiyu Zhu, Chao Zhao*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Many treatments have been used for glucose metabolism diseases such as type 2 diabetes, and all of those treatments have several advantages as well as limitations. This review introduces a 3D co-culture intestinal organoid system developed from stem cells, which has the special function of simulating human tissues. Recent studies have revealed that the gut is an important site for exploring the interactions among glucose metabolism, gut microbial metabolism, and gut microbiota. Therefore, 3D intestinal organoid systems can be used to imitate the congenital errors of human gut development, drug screening, food transportation and toxicity analysis. The intestinal organoid system construction methods and their progress as compared with traditional 2D culture methods have also been summarised in the manuscript. This paper discusses the research progress in terms of intestinal organoids applicable to glucose metabolism and provides new ideas for developing anti-diabetic drugs with high efficiency and low toxicity.

Original languageEnglish
Article number100402
JournalCurrent Research in Food Science
Volume6
DOIs
Publication statusPublished - Jan 2023

Bibliographical note

Publisher Copyright:
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Keywords

  • 3D co-culture
  • Glucose metabolism
  • Intestinal organoid

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