Abstract
Thiolated polymers are commonly preferred for biomedical applications with their good permeation properties providing them higher bioavailability. However, the thiolation process is mostly time-consuming series of chemical reactions. This study describes a simple irreversible thiol group integration to the pectin hydrogels by noncovalent bonding. We used 2-thiobarbituric acid (TBA) for thiolation. We proved with full-atom molecular dynamics simulations and experimental methods that TBA desertion is negligible. Pectin hydrogels become more flexible and their disintegration is delayed from 4 h up to four days with TBA addition. Also, hydrogels can successfully deliver the model drug, theophylline, showing a controlled release profile.
| Original language | English |
|---|---|
| Pages (from-to) | 703-711 |
| Number of pages | 9 |
| Journal | International Journal of Polymeric Materials and Polymeric Biomaterials |
| Volume | 70 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2021 |
Bibliographical note
Publisher Copyright:© 2020 Taylor & Francis Group, LLC.
Funding
This work was funded by The ITU Scientific Research Office (BAP) with MGA-2018-41165 of project number. We sincerely thank Herbstrith & Fox company (Germany) for providing low-methylated pectin.
| Funders | Funder number |
|---|---|
| Herbstrith & Fox company | |
| ITU Scientific Research Office | |
| British Association for Psychopharmacology | MGA-2018-41165 |
Keywords
- Biopolymers
- drug delivery systems
- hydrogels
- molecular dynamics
- simulations