Keyphrases
Hereditary Spastic Paraplegia
100%
Novel Candidate Genes
50%
Loss Function
50%
Transgenic Mice
50%
Gain-of-function
50%
Gene-based
50%
Function Components
50%
Axonal Swelling
50%
Spastin Gene
50%
Autosomal Dominant
50%
Corticospinal Tract
40%
Gait
40%
Dieback
40%
Spastin
30%
SPG4
30%
Vertebrate Model
20%
VPS16
12%
Exome Sequencing
12%
Transgenic Mouse Lines
10%
Microtubule-severing Proteins
10%
Behavior Analysis
10%
Early Onset
10%
Gene Knockout Mice
10%
Etiology
10%
Toxic Effects
10%
Potential Therapy
10%
Histological Analysis
10%
Histone Deacetylase 6 (HDAC6)
10%
Hand Mouse
10%
Disease Pathology
10%
Effective Therapy
10%
Axon
10%
Gene Knockout
10%
Most Common Form
10%
Rosa26 Locus
10%
Mutant Protein
10%
Parental Lines
10%
Tubulin Post-translational Modifications
10%
Crossbred Cows
10%
Segregation Patterns
6%
Neurodegenerative Diseases
6%
Turkish Family
6%
Clinical Heterogeneity
6%
Causative Variant
6%
Disease Genes
6%
Genetic Heterogeneity
6%
Muscle Weakness
6%
Family Members
6%
Penetrant
6%
Allele Frequency
6%
Biochemistry, Genetics and Molecular Biology
Candidate Gene
50%
Exome Sequencing
50%
Autosomal Dominant Inheritance
50%
Spastin
50%
Transgenic Mouse
50%
Nerve Fiber Degeneration
35%
Penetrance
25%
Gene Frequency
25%
Cell Function
25%
Dideoxynucleotide Sequencing
25%
Gene Targeting
14%
Gene Knockout
14%
Tubulin
7%
Mutant Protein
7%
Histone Deacetylase
7%
Progeny
7%
Medicine and Dentistry
Transgenic Mouse
50%
DeJerine-Sottas Disease
50%
Spastin
50%
Nerve Fiber Degeneration
35%
Disease
35%
Gene Targeting
14%
Gene Knockout
14%
Toxicity
7%
Tubulin
7%
Mutant Protein
7%
Histone Deacetylase
7%
Progeny
7%
Microtubule
7%